Understanding the Importance and Impact of Technology in an Accounting Setting: Work Outcomes and Relationships with Clients

This study explores how technology positively or negatively impacts the accounting profession, and specifically, the impact on work outcomes (i.e. the effectiveness and efficiency of work) and relationships with clients. Three types of technology tools were featured in this study: Accounting and Analytics, Robotic Process Automation, and Communication Technology Tools and Platforms. Our research questions were (1) How much do technology tools improve the efficiency and effectiveness of the accountant? and (2) How much do technology tools affect the relationship with clients? After surveying professionals in the accounting field, we concluded that accountants believe that Communication softwares improve their efficiency and effectiveness the most, with Accounting and Analytics softwares just behind. We can also conclude that technology has a positive, or at the very least, neutral, effect on the relationship between professionals and their clients. Overall, it was found that in the accounting field, technology has a positive impact on work outcomes and relationships with clients

Analysis of pmpD Expression and PmpD Post-Translational Processing during the Life Cycle of Chlamydia trachomatis Serovars A, D, and L2

BACKGROUND: The polymorphic membrane protein D (PmpD) in Chlamydia is structurally similar to autotransporter proteins described in other bacteria and may be involved in cellular and humoral protective immunity against Chlamydia. The mechanism of PmpD post-translational processing and the role of its protein products in the pathogenesis of chlamydial infection have not been very well elucidated to date. METHODOLOGY/PRINCIPAL FINDINGS: Here we examined the expression and post-translational processing of the protein product of the pmpD gene during the life cycle of C. trachomatis serovars A, D, and L2. Each of these three serovars targets different human organs and tissues and encodes a different pmpD gene nucleotide sequence. Our quantitative real-time reverse transcription polymerase chain reaction results demonstrate that the pmpD gene is up-regulated at 12-24 hours after infection regardless of the Chlamydia serovar. This up-regulation is coincidental with the period of exponential growth and replication of reticulate bodies (RB) of Chlamydia and indicates a probable similarity in function of pmpD in serovars A, D, and L2 of Chlamydia. Using mass spectrometry analysis, we identified the protein products of post-translational processing of PmpD of C. trachomatis serovar L2 and propose a double pathway model for PmpD processing, with one cleavage site between the passenger and autotransporter domains and the other site in the middle of the passenger domain. Notably, when Chlamydia infected culture cells were subjected to low (28 degrees C) temperature, PmpD post-translational processing and secretion was found to be uninhibited in the resulting persistent infection. In addition, confocal microscopy of cells infected with Chlamydia confirms our earlier hypothesis that PmpD is secreted outside Chlamydia and its secretion increases with growth of the chlamydial inclusion. CONCLUSION/SIGNIFICANCE: The results of this current study involving multiple Chlamydia serovars support the general consensus that the pmpD gene is maximally expressed at mid infection and provide new information about PmpD as an autotransporter protein which is post-translationally processed and secreted outside Chlamydia during normal and low temperature induced persistent chlamydial infection

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

The Effect of Instagram Popularity on Perception and Self-Esteem

Previous research suggests that the use of social media can have psychological impacts (e.g. depression, self-esteem issues). The purpose of our study was to determine whether the way we perceive the likability and attractiveness of others, as well as our own self-esteem, is influenced by Instagram popularity. There were three experimental groups; all groups viewed the same three Instagram posts that differed only in number of likes and comments. The low popularity images showed 10-14 likes, average popularity 100-120 likes, and high popularity 1,000-1,020 likes. Participants viewed each image for 1 min. After viewing the posts, participants were asked to rate the girl in each photo from 1 (extremely unattractive) to 10 (extremely attractive). Participants were then instructed to complete the Reysen Likability Scale to measure the likability of the subject of the images and the Rosenberg Self-Esteem Scale to measure the participants self-esteem. It is expected that participants in the low popularity group will perceive the person pictured as less attractive and less likable, and rate their own self-esteem as higher compared to those in the high popularity group who will perceive the person as more attractive and likable, and rate their self-esteem as lower

The Influence of Knee and Ankle Bracing on Lower Extremity Kinematics During a Cutting Maneuver

PURPOSE: To determine the effect of four brace conditions on the lower extremity kinematics during a jogging cutting maneuver. METHODS: 18 subjects (9 male and 9 female, age = 22.8±2.0 yrs, ht = 174.7±7.6 cm, wt = 74.9±14.5 kg) participated in this study. Each subject performed 7–10 jogging cutting trials while wearing each of the four brace conditions; ankle brace only (AB), knee brace only (KB), ankle and knee brace together (ABKB) and no brace (NB). Hip and knee sagittal and frontal plane kinematics and ankle sagittal plane kinematics were assessed for each subject during each of the brace conditions. RESULTS: ANOVA (α = .05) revealed that sagittal plane ankle and hip ROM were not influenced by brace condition. Sagittal plane knee ROM was significantly reduced in the KB compared to the NB condition. Frontal plane knee ROM revealed a more varus position during the KB and ABKB conditions compared to the NB and AB conditions. The results also revealed that the hip was significantly more abducted during the KB and ABKB conditions when compared to the AB and NB conditions. CONCLUSIONS: The results indicate that the KB and the ABKB significantly influenced frontal plane hip and knee ROM and sagittal plane knee ROM during a jogging cutting maneuver. These braces may be beneficial in preventing excessive motion at the respective joint however it is important to consider their impact at the hip joint as a result of these bracing techniques. It is possible that these changes in ROM may result in subsequent changes in joint moments and or ground reaction forces

Traits and phylogenetic history contribute to network structure across Canadian plant-pollinator communities

Interaction webs, or networks, define how the members of two or more trophic levels interact. However, the traits that mediate network structure have not been widely investigated. Generally, the mechanism that determines plant-pollinator partnerships is thought to involve the matching of a suite of species traits (such as abundance, phenology, morphology) between trophic levels. These traits are often unknown or hard to measure, but may reflect phylogenetic history. We asked whether morphological traits or phylogenetic history were more important in mediating network structure in mutualistic plant-pollinator interaction networks from Western Canada. At the plant species level, sexual system, growth form, and flower symmetry were the most important traits. For example, species with radially symmetrical flowers had more connections within their modules (a subset of species that interact more among one another than outside of the module) than species with bilaterally symmetrical flowers. At the pollinator species level, social species had more connections within and among modules. In addition, larger pollinators tended to be more specialized. As traits mediate interactions and have a phylogenetic signal, we found that phylogenetically close species tend to interact with a similar set of species. At the network level, patterns were weak, but we found increasing functional trait and phylogenetic diversity of plants associated with increased weighted nestedness. These results provide evidence that both specific traits and phylogenetic history can contribute to the nature of mutualistic interactions within networks, but they explain less variation between networks

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33)